GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13010639 | 1 | rs12995739 | chr2:231037481 | SP110 | chr2:231033645-231084827:- | 0.22 | 4.02 | 6.33E-5 | Obesity-related traits |
| BRCA | cis | rs6708331 | 1 | rs12999430 | chr2:70306785 | FAM136A | chr2:70523109-70529220:- | -0.11 | -3.68 | 0.00024 | Obesity-related traits |
| BRCA | cis | rs6708331 | 1 | rs13000817 | chr2:70273707 | FAM136A | chr2:70523109-70529220:- | -0.11 | -3.5 | 0.000484 | Obesity-related traits |
| BRCA | cis | rs950880 | 1 | rs13001325 | chr2:102939036 | IL18R1 | chr2:102927962-103015215:+ | 0.11 | 4.89 | 1.15E-6 | Serum protein levels (sST2) |
| BRCA | cis | rs13004237 | 1 | rs13004237 | chr2:172833139 | SLC25A12 | chr2:172639915-172750813:- | 0.13 | 3.6 | 0.000332 | Schizophrenia |
| BRCA | cis | rs12989701 | 1 | rs13004848 | chr2:127887560 | BIN1 | chr2:127805607-127864864:- | 0.19 | 4.85 | 1.39E-6 | Alzheimer's disease (late onset) |
| BRCA | cis | rs67766926 | 1 | rs13008738 | chr2:61078921 | AHSA2 | chr2:61404553-61414058:+ | -0.13 | -5.2 | 2.38E-7 | Inflammatory skin disease |
| BRCA | cis | rs67766926 | 1 | rs13008738 | chr2:61078921 | C2orf74 | chr2:61372243-61391964:+ | 0.28 | 5.93 | 4.1E-9 | Inflammatory skin disease |
| BRCA | cis | rs13010639 | 1 | rs13010998 | chr2:231035729 | SP110 | chr2:231033645-231084827:- | 0.2 | 3.76 | 0.000181 | Obesity-related traits |
| BRCA | cis | rs13014235 | 1 | rs13014235 | chr2:202215492 | ALS2CR12 | chr2:202153148-202222101:- | -0.2 | -5.25 | 1.81E-7 | Basal cell carcinoma |
| BRCA | cis | rs13014235 | 1 | rs13014235 | chr2:202215492 | PPIL3 | chr2:201735680-201753999:- | -0.18 | -4.94 | 9.2E-7 | Basal cell carcinoma |
| BRCA | cis | rs10205487 | 1 | rs13015457 | chr2:70125763 | ANXA4 | chr2:69969127-70053594:+ | -0.14 | -4.02 | 6.35E-5 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs10205487 | 1 | rs13015457 | chr2:70125763 | FAM136A | chr2:70523109-70529220:- | -0.09 | -3.51 | 0.000459 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs13016963 | 1 | rs13016963 | chr2:202162811 | ALS2CR12 | chr2:202153148-202222101:- | -0.24 | -6.18 | 9.24E-10 | Melanoma;Esophageal squamous cell carcinoma |
| BRCA | cis | rs950880 | 1 | rs13019081 | chr2:102950822 | IL18R1 | chr2:102927962-103015215:+ | -0.1 | -4.35 | 1.49E-5 | Serum protein levels (sST2) |